The Bernstein Lab
  • Home
  • Research Projects
  • Lab Members
  • Publications
  • Bio
  • News
  • Links
  • Contact

Current Lab Members

Picture
Kara Bernstein

Lab Head

B.A. Bryn Mawr College, 2000
Ph.D. Yale University, 2006 (Advisor Susan Baserga)
Post-doctorate Fellow, Columbia University, 2006-2011 (Advisor Rodney Rothstein)


Picture
Michael Mihalevic

Laboratory Technician
July 1, 2011 - current

B.S. University of Pittsburgh, 2011

Lab Publications:


Westmoreland J.W., Mihalevic M.J., Bernstein K.A., Resnick M.A. (2018) The global role for Cdc13 and Yku70 in preventing telomere resection across the genome, ​DNA Repair, 62: 8-17.

Varlakhonava, N.V., Michaelvic, M.J., Bernstein, K.A., Ford, M.G.J. (2017) Pib2 is required for EGO complex-dependent activation of TORC1, Journal of Cell Science, 130(22): 3878-3890.

Zacchi, L.F., Dittmar, J.C., Mihalevic, M.J., Shewan, A.M., Schulz, B.L., Brodsky, J.F., Bernstein, K.A. (2017) A novel high-throughput yeast genetic screen for factors modifying protein levels of the Early-Onset Torsion Dystonia-associate variant torsinA∆E, Disease Models and Mechanisms, 10(9): 1129-1140.

Godin, S.K., Zhang, Z., Herken, B.W., Westmoreland, J.W., Lee, A.G., Mihalevic, M.J., Yu, Z., Sobol, R.W., Resnick, M.A., Bernstein, K.A. (2016) The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products, Nucleic Acids Research, 44(17): 8199-8215.

B
öhm, S., Szakal, B., Herken, B.W., Sullivan, M.R., Mihalevic, M.J., Kabbinavar, F.F., Branzei, D., Clark, N.L., Bernstein, K.A. (2016) The budding yeast ubiquitin protease Ubp7 is a novel component involved in S-phase progression, Journal of Biological Chemistry, 291(9): 4442.

Godin, S.K., Meslin, C., Kabbinavar F., Bratton-Palmer, D.S., Hornack, C., Mihalevic, M.J., Yoshida, K., Sullivan, M., Clark, N.L.*, Bernstein, K.A.* (2015) Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens,
Genetics, 199(4): 1023-1033.*Co-corresponding
*Issue Highlight for the Genetics journal and featured on SGD

B
öhm, S.,
Mihalevic, M.J., Casal, M.A., and Bernstein, K.A., (2015) Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells, DNA Repair, 26: 1-14.


Bernstein, K.A., Mimitou, E.P., Mihalevic, M.J., Chen, H., Sunjaveric, I., Symington, L.S., Rothstein R. (2013) Resection activity of the Sgs1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae, Genetics,
195(4): 1241-1251.
*Issue Highlight for the Genetics journal



Picture
McKenzie Grundy

Laboratory Technician
​March 6, 2018 - present

​B.S. Chatham University, 2017



Picture
Gregory Brunette

Laboratory Technician
August 15, 2016 - current

B.S. University of Pittsburgh, 2016

Lab Publications:

Kondrashova O., Nguyen M., Shield-Artin K., Tinker A.V., Teng N.N.H., Harrell M.I., Kuiper M.J., Ho G.Y., Barker H., Jasin M., Prakash R., Kass E.M., Sullivan M.R., Brunette G.J., Bernstein, K.A., Coleman R.L., Floquet A., Friedlander M., Kichenadasse G., O'Malley D.M., Oza A.M., Sun J.X., Robillard L., Maloney L., Bowtell D.D.L., Giordano H, Wakefield M.J., Kaufmann S.H., Simmons A.D., Harding T.C., Raponi M., McNeish I.A., Swisher E.M., Lin K., Scott C.L. (2017) Secondary somatic mutations restoring RAD51C and RAD51D associated with acquired resistance to the PARP inhibitor Rucaparib in high-grade ovarian carcinoma, Cancer Discovery, 7(9):984-998.
*Featured on Cover

Picture
Meghan Sullivan

Graduate Student
July 1, 2014 - current

B.A. University of Rochester


Funding: National Institutes of Health Pre-doctoral Fellowship (F31ES027321)

Lab Publications:


Kondrashova O., Nguyen M., Shield-Artin K., Tinker A.V., Teng N.N.H., Harrell M.I., Kuiper M.J., Ho G.Y., Barker H., Jasin M., Prakash R., Kass E.M., Sullivan M.R., Brunette G.J., Bernstein, K.A., Coleman R.L., Floquet A., Friedlander M., Kichenadasse G., O'Malley D.M., Oza A.M., Sun J.X., Robillard L., Maloney L., Bowtell D.D.L., Giordano H, Wakefield M.J., Kaufmann S.H., Simmons A.D., Harding T.C., Raponi M., McNeish I.A., Swisher E.M., Lin K., Scott C.L. (2017) Secondary somatic mutations restoring RAD51C and RAD51D associated with acquired resistance to the PARP inhibitor Rucaparib in high-grade ovarian carcinoma, Cancer Discovery, 7(9):984-998.
*Featured on Cover

Godin, S.K., Sullivan, M.R., Bernstein, K.A. (2016) Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication, Biochemistry and Cell Biology, 94: 1-12.

McClendon, T.B.*, Sullivan, M.R.*, Bernstein, K.A.*, Yanowitz, J.L.* (2016) Promotion of homologous recombination by SWS-1 in complex with RAD-51 paralogs in Caenorhabditis elegans, Genetics, 203(1): 133-145. *Equal contribution

*Featured as a Genetics Primer [Turcotte, C.A., Andrews, N.P., Sloat, S.A., Checchi, P.M. CRISPR Technology Reveals RAD(51)-ical Mechanisms of Repair in Roundworms: An Educational Primer for Use with “Promotion of Homologous Recombination by SWS-1- in Complex with RAD-51 Paralogs in Caenorhabditis elegans” (2016) Genetics 204: 883-891]

Böhm, S., Szakal, B., Herken, B.W., Sullivan, M.R., Mihalevic, M.J., Kabbinavar, F.F., Branzei, D., Clark, N.L., Bernstein, K.A. (2016) The budding yeast ubiquitin protease Ubp7 is a novel component involved in S-phase progression, Journal of Biological Chemistry, 291(9): 4442.

Godin, S.K., Meslin, C., Kabbinavar F., Bratton-Palmer, D.S., Hornack, C., Mihalevic, M.J., Yoshida, K., Sullivan, M., Clark, N.L.*, Bernstein, K.A.* (2015) Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens, Genetics, 199(4): 1023-1033. *Co-corresponding
*Issue Highlight for the Genetics Journal and featured on SGD


Picture
Braulio Bonilla

Graduate Student
June 1, 2016 - current

Licentiate in Biology, Universidad de la Republica, Uruguay, 2008

Funding: Fulbright Scholar


Picture
Thong Luong

Graduate Student
May 29, 2017 - current

B.S., University of Tennessee, 2011




Picture
  Sarah Hengel

  Post-Doctorate Fellow

  B.S., College of Saint Scholastica, 2010
  Ph.D. University of Iowa, 2017 (Advisor, Maria Spies)

  Funding: 2017 Diversity Supplement from the National Institutes of Health



Picture
Julieta Martino

Post-Doctorate Fellow
June 8, 2015 - current

Licentiate in Biology, Universidad Nacional de Córdoba, Argentina, 2005
Ph.D. University of Maine, 2015 (Fulbright scholar, Advisor John Wise)

Lab Publications: Martino, J., and Bernstein, K.A. (2016) The Shu complex is a conserved regulator of homologous recombination, FEMS Yeast Research, In press.

Picture
Robert Baldock

Post-doctorate Fellow
June 7, 2016 - current

B.Sc. (Hons) University of Sussex, UK, 2012
Ph.D. University of Sussex, 2016 (Advisor Felicity Watts)


Picture
Anton Khodakov

Medical Student Researcher University of Pittsburgh, Class of 2018
April 16, 2015 - current

B.A. Harvard University, 2014

Funding: Dean's Summer Research Program

Picture
Catherine Pressimone

Undergraduate Researcher
September 7, 2015 - current

Funding: 2016 Diversity Supplement from the National Institutes of Health

Picture
Chelsea Smith

Undergraduate Researcher
September 11, 2017 - current

Funding:  2018 Chancellor's Research Fellowship (Fall Semester)
               2018 Honors College Health Sciences Summer Research Fellowship
               2018 Dietrich School Summer Undergraduate Research Award (Declined)

​